First Cases of Sars-cov-2 Reinfection Coinciding with the Covid-19 Second Wave, Benin City, Nigeria.

BACKGROUND: Reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has important public health implications pertaining to herd immunity and durability of protection from vaccines. A small but growing number of cases have been reported globally but none from Africa. This is due, in part, to adherence to definitions based on genetic sequencing, the capabilities of which are in short supply on the continent. METHODS: Based on epidemiological and clinical parameters, we report the first two cases of SARS-CoV-2 reinfection from a Nigerian tertiary hospital managing coronavirus disease 2019 (COVID-19) patients. RESULT: Two cases of SARS-CoV-2 reinfection were seen in December, 2020 and January, 2021. Both were males associated with a healthcare setting and aged 37 and 38 years respectively. The number of days between the first infection and the second ranged from 160-196 days. Symptoms ranged from mild to moderate and they recovered without sequelae. CONCLUSION: Public health action, including risk communication and reinfection surveillance backed by genomic sequencing, is advocated.

CONTEXTE: La réinfection par le coronavirus 2 du syndrome respiratoire aigu sévère (SRAS-CoV-2) a des implications importantes pour la santé publique en ce qui concerne l'immunité du troupeau et la durabilité de la protection contre les vaccins. Un nombre petit mais croissant de cas a été signalé dans le monde, mais aucun en Afrique. Cela est dû, en partie, au respect des définitions basées sur le séquençage génétique, dont les capacités sont rares sur le continent. MÉTHODES: Sur la base de paramètres épidémiologiques et cliniques, nous rapportons les deux premiers cas de réinfection par le SRAS-CoV-2 d'un hôpital tertiaire nigérian prenant en charge des patients atteints de la maladie à coronavirus 2019 (COVID-19). RÉSULTAT: Deux cas de réinfection par le SRAS-CoV-2 ont été observés en décembre 2020 et janvier 2021. Tous deux étaient des hommes associés à un établissement de soins de santé et âgés respectivement de 37 et 38 ans. Le nombre de jours entre la première infection et la seconde variait de 160 à 196 jours. Les symptômes variaient de légers à modérés et ils se sont rétablis sans séquelles. CONCLUSION: Une action de santé publique, y compris la communication des risques et la surveillance des réinfections appuyées par le séquençage génomique, est préconisée. MOTS CLÉS: COVID-19; SRAS-CoV-2; Réinfection; Nigeria; Pandémie.

Healthcare Workers' Preparedness to tackle COVID-19: A Study on Knowledge and Compliance with Standard Precautions in a Tertiary Hospital in Southern Nigeria

AJOL Abstract: Background: Hospitals may serve as amplifiers of infectious disease rates during outbreak situations. The strict implementation of and compliance with standard precautions (SPs) is the primary strategy for preventing healthcare-associated infections. This study was conducted to assess the knowledge and level of compliance with SPs in a tertiary hospital as a measure of preparedness to tackle the COVID-19 pandemic.Methods: This descriptive cross-sectional study was conducted among healthcare workers selected using stratified sampling technique in the University of Benin Teaching Hospital, Benin City, Nigeria during the COVID-19 pandemic. Data was collected using an adapted, self-administered questionnaire and analyzed using IBM SPSS version 25.0. Knowledge and compliance with SPs were assessed using six domains each. Statistical measures for analysis were the odds ratios (OR) and 95% confidence intervals (CI). The level of significance was set at p < 0.05.Results: A total of 524 respondents with mean age 38.1 ± 9.7 years participated in this study. Majority, 432 (84.2%) were female and 467 (89.1%) were clinical staff. Overall, knowledge and compliance of SPs were good in 457 (87.2%) and 293 (60.0%) respondents, respectively. Clinical health workers were 2.5 (95% CI: 1.3 - 5.1) times more likely to have good knowledge while respondents with poor knowledge were 0.5 (95% CI: 0.3 - 0.9) timesless likely to have good compliance with SPs.Conclusion: Knowledge of SPs in the studied population was high and compliance was good. Continued education and behavioural change communication are needed to improve compliance especially in the face of a pandemic